منابع مشابه
Prednisolone or pentoxifylline for alcoholic hepatitis.
BACKGROUND Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease exceeds 30%. Prednisolone and pentoxifylline are both recommended for the treatment of severe alcoholic hepatitis, but uncertainty about their benefit persists. ...
متن کاملPentoxifylline and prednisolone in severe alcoholic hepatitis.
published under the permission of the editor ofWorld J Gastroenterol All authors disclosed that there is no conflict of interest with authors or institutions referred in the manuscript.
متن کاملPentoxifylline Plus Prednisolone versus Pentoxifylline Only for Severe Alcoholic Hepatitis: A Randomized Controlled Clinical Trial
BACKGROUND Prednisolone and pentoxifylline (PTX) have been shown to be individually useful in severe alcoholic hepatitis with Maddrey discriminant function (MDF) score ≥32. Previous report suggests that PTX is probably superior to prednisolone alone. However the efficacy of PTX and prednisolone combination over PTX alone in the management of acute alcoholic hepatitis (MDF score ≥32) is yet unre...
متن کاملPentoxifylline in severe alcoholic hepatitis: a prospective, randomised trial.
BACKGROUND Role of corticosteroids in treatment of severe alcoholic hepatitis (SAH) is controversial. Pentoxifylline (PTX), an inhibitor of TNF, has also been shown to decrease short term mortality in SAH. Aim of this study was to evaluate the effect of PTX on short term mortality, renal and hepatic functions in patients with SAH. METHODS Fifty patients with SAH {Maddrey's Discriminant Functi...
متن کاملTreatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline.
Despite being themost frequently abused drug for centuries, alcohol was not recognized as a direct hepatotoxin until the 1960s.1 Alcohol abuse accounts for the third leading preventable causeofdeath and the secondmost commoncauseof cirrhosis after hepatitis C virus infection in the United States.2,3 Alcoholichepatitis is a commoncomplicationofalcohol abuse; its severity can range frommild to se...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2009
ISSN: 1465-1858
DOI: 10.1002/14651858.cd007339.pub2